PEG-Containing Polymeric Films and Gels as Postoperative Tissue Adhesion Barriers

Abstract:

This study was designed to evaluate the effect of polyethylene glycol (PEG) and nonsteroidal anti-inflammatory drug (ibuprofen) on the prevention of postoperative tissue adhesion. For this, we synthesized poly(L-lactic acid)-PEG diblock copolymers and used them to prepare ibuprofen-loaded films as tissue adhesion barrier films. We also prepared lower critical solution temperature (LCST)-controllable Pluronic F127/F68 mixtures including mildly crosslinked alginate and ibuprofen as tissue adhesion barrier gels. The prepared films and gels with/without ibuprofen were evaluated by the observations of peritoneal tissue adhesion via animal study using a rat model.