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Poly-N-Acetyl Glucosamine as a Scaffold for Cartilage Tissue Engineering in Nude Mice

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Abstract:

Athymic nude mice were used as an animal model to evaluate the chondrogenic effects of bovine fetal chondrocytes seeded onto a new poly-N-acetyl glucosamine sponge. Results show excellent hyaline-like cartilage formation with high glycosaminoglycan concentration after 6 weeks. At 4 weeks there is less cartilage formation and more fibrous tissue infiltrate. Although further studies are needed, these initial data support the use of poly-N-acetyl glucosamine sponge as a scaffold for cartilage tissue engineering.

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Periodical:

Key Engineering Materials (Volumes 288-289)

Pages:

71-74

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.288-289.71

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Online since:

June 2005

Authors:

Christopher M. Hill, Yuehuei H. An, Qian K. Kang, Marina V. Demcheva, S.William Whitson, John Vournakis

Keywords:

Cartilage, Glucosamine, Nude Mice, Poly-N-Acetyl, Scaffold, Tissue Engineering

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© 2005 Trans Tech Publications Ltd. All Rights Reserved

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