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Biomimetic Synthesis of Apatite - Polyelectrolyte Complex (Chitosan - Phosphorylated Chitosan) Hydrogel as an Osteoblast Carrier

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Abstract:

A novel three-dimensional scaffold of hydroxyapatite(HA)-polyelectrolyte complex (PEC) composite hydrogel was synthesized by a biomimetic method. PEC hydrogel was formed from equal volumes of 1% phosphorylated chitosan in water and 1% chitosan in 1% acetic acid solution. This PEC hydrogel was soaked in saturated Ca(OH)2 solution for 4 d and then in accelerated calcification solution (ACS) for 7 d, both at 37 oC. The PEC hydrogel was a nano-composite material with multiple levels of hierarchical porosity; hydroxyapatite (HA) crystals nucleated and grew on the fiber surfaces of the hydrogel; Rat osteoblasts were then seeded in this three-dimensional scaffold of HA-PEC composite hydrogel, the three-dimensional scaffold of HA-PEC hydrogel revealed excellent biocompatibility.

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Advanced Biomaterials VI View Preview

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Periodical:

Key Engineering Materials (Volumes 288-289)

Pages:

75-78

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.288-289.75

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Online since:

June 2005

Authors:

Quan Li Li, Zhi Qing Chen, Guo Min Ou, Laikui Liu, Hao Bin Jiang, Quan Zeng, Gang Li, G. He, An Chun Mo, Brian W. Darvell

Keywords:

Biomineralization, Chitosan (CS), Osteoblast, Phosphorylated Chitosan, Polyelectrolyte Complex (PEX)

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© 2005 Trans Tech Publications Ltd. All Rights Reserved

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