Paper Titles
Pull-Out Strength Analysis of Quartz Fibre Posts in Dental Implants
p.130
Polymer Scaffolds for Tissue Engineering
p.136
Preparation of Highly Porous Hydroxyapatite Ceramics from Cuttlefish Bone
p.142
Strong Biomimetic Hydroxyapatite Scaffolds
p.148
Fabrication and In-Vitro Characterization of Three-Dimensional Composite Scaffolds by Robocasting for Biomedical Applications
p.153
Mineralized Scaffolds for Hard Tissue Engineering by Ionotropic Gelation of Alginate
p.159
Development of Bioabsorbable DURA MATER
p.165
Guided Bone Regeneration, Platelet Rich Plasma and Low-Intensity Ultrasound Irradiation for Dental Implants
p.171
Guided Bone Engineering: Healing of Large Bone Defects
p.181

Fabrication and In-Vitro Characterization of Three-Dimensional Composite Scaffolds by Robocasting for Biomedical Applications

Article Preview

Abstract:

The development of novel biodegradable scaffolds for the treatment of bone and cartilage defects is the subject of intense research. A successful scaffold will guide cell-attachment, proliferation and tissue regeneration. The objective of this study is to use freeform fabrication (robocasting) for the preparation of porous hybrid organic/inorganic materials with a well controlled architecture and porosity. Polymer/hydroxyapatite (HA) pastes with ceramic contents ranging between 0 to 70 wt. % are prepared by mixing ceramic powders with a solution of the polymer in methylene chloride. Two different polymers are studied: polylactide (PLA) and polycaprolactone (PCL). During the compression tests, the scaffolds show an elasto-plastic behavior with large plastic yielding and do not fail in a brittle manner. The mechanical response is anisotropic and depends significantly on the ceramic content and the type of polymer.

You might also be interested in these eBooks
Materials in Clinical Applications VII View Preview

Info:

Periodical:

Advances in Science and Technology (Volume 49)

Pages:

153-158

DOI:

https://doi.org/10.4028/www.scientific.net/AST.49.153

Citation:

Cite this paper

Online since:

October 2006

Authors:

J. Russias, Eduardo Saiz, Sylvain Deville, Antoni P. Tomsia

Keywords:

Composite, Implant, Mechanical Property, Scaffold, Solid Freeform Fabrication

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2006 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

References

[1] D. W. Hutmacher, Biomaterials, 2000, 21, 2529.

Google Scholar

[2] R. F. Service, Science, 2000, 289, 1498.

Google Scholar

[3] K. J. L. Burg, S. Porter, J. F. Kellam, Biomaterials, 2000, 21, 2347.

Google Scholar

[4] W. Cheng, H. Y. Li, J. Chang, Materials Letters, 2005, 59, 2214.

Google Scholar

[5] A. M. A. Ambrosio, J. S. Sahota, Y. Khan, C. T. Laurencin, Journal of Biomedical Materials Research, 2001, 58, 295.

Google Scholar

[6] L. M. Matthieu et al., Biomaterials, 2006, 27, 905.

Google Scholar

[7] D. W. Hutmacher, M. Sittinger, M. V. Risbud, Trends in Biotechnology, 2004, 22, 354.

Google Scholar

[8] G. Vozzi, C. Flaim, A. Ahluwalia, S. Bhatia, Biomaterials, 2003, 24, 2533.

Google Scholar

[9] S. J. Kalita, S. Bose, H. L. Hosick, A. Bandyopadhyay, Materials Science & Engineering CBiomimetic and Supramolecular Systems, 2003, 23, 611.

Google Scholar

[10] I. Grida, J. R. G. Evans, Journal of the European Ceramic Society, 2003, 23, 629.

Google Scholar

[11] J. H. Kinney, M. C. Nichols, Annual Review of Materials Science, 1992, 22, 121.

Google Scholar

[12] T. kokubo, H. Kushitani, S. Sakka, T. Kitsugi, T. Yamamuro, Journal of Biomedical Materials Research, 1990, 24, 721.

DOI: 10.1002/jbm.820240607

Google Scholar

[13] P. B. ODonnell, J. W. McGinity, Advanced Drug Delivery Reviews, 1997, 28, 25.

Google Scholar

[14] S. J. Hollister, Nature Materials, 2005, 4, 518.

Google Scholar

[15] J. E. Smay, J. Cesarano, J. A. Lewis, Langmuir, 2002, 18, 5429.

Google Scholar

[16] S. Michna, W. Wu, J. A. Lewis, Biomaterials, 2005, 26, 5632.

Google Scholar

[17] E. Luong-Van et al., Biomaterials, 2006, 27, (2042).

Google Scholar

[18] R. Murugan, S. Ramakrishna, Composites Science and Technology, 2005, 65, 2385.

Google Scholar