Papers by Keyword: Folate (FA)

Abstract: Nano-Fe₃O₄ magnetic particles were prepared by ultrasonic emulsion method and then were dispersed into water with chitosan or folate as surfactants for biocompatible water-based Fe₃O₄ magnetic fluid. The cubic inverse spinel structure of Fe₃O₄ nanoparticles were analyzed by X-ray diffraction technique (XRD). The saturation magnetizations of different magnetic particles were tested by a vibrating sample magnetometer (VSM). The morphologies of nanoparticles were observed by transmission electron microscope (TEM). The particle size was about uniform 10-20 nm, and their shape was approximately spherical. Meanwhile, dispersity was improved markedly after the surface modification. Comparing to magnetic fluid with chitosan modification, magnetic fluid was coated with chitosan and folate gets higher dispersity and stability when both of them have same saturation magnetizations.

Abstract: Drug delivery systems with active targeting ligand provide improved therapeutic efficiency due to the selectivity towards tumor cells. In this paper we prepared drug loaded nanoparticles (NPs) using folate (FA) incorporated chitosan (FA-CS) based on ionic gelation technology. FA-CS NPs were spherical in shape with an average particle size of 100 nm, while 5-fluorouracil (5-FU) loaded NPs became less circular with average particle size of 100-500 nm. NPs made from FA-CS conjugates exhibited improved capability to encapsulate hydrophilic 5-FU. It was found 5-FU distributed in FA-CS NPs in solid solution state. In vitro release results demonstrated the release of 5-FU from FA-CS NPs was more controllable as compared to that of CS NPs.

Abstract: Anticancer drugs are always restricted as lacking of tumor cell-selective targeting. In this paper, to achieve double effects of targeting and decreasing the drug toxicity, the folate (FA) -O-carboxymethyl chitosan (O-CMC) and the methotrexate (MTX) encapsulated FA-O-CMC/CaCl2 nanoparticles were prepared. The numbers of FA conjugated to O-CMC, particle size, surface morphology, encapsulation efficiency and loading efficiency of the obtained nanoparticles were characterized. The results showed that the FA-O-CMC possessing targeting ability was achieved. MTX had been successfully loaded into the nanoparticles. The prepared nanoparticles were spherical in morphology with an average size of 322 nm

Abstract: To improve the specific accumulation in tumor sites and aqueous solubility of atRA, the core-shell type of folate-PEG-g-PEI/atRA nanoparticles were prepared by complexation between cationic PEI segments in the copolymers and anionic charged atRA, and then characterized by 1HNMR, ELS, XRD, and TEM. In vitro atRA release from the nanoparticles was investigated as a function of drug content in sink condition. Cytotocicity of atRA against HepG2, KB cell lines were also evaluated by MTT assay. The lower the drug content, the faster atRA release. atRA incorporated in folate-PEG-g-PEI/atRA nanoparticles showed much higher cytotoxic effect compared with atRA itself.