Papers by Keyword: pHEMA

Abstract: Magnetic nanocomposite films of the Fe3O4/pHEMA were prepared by dispersing the Fe3O4 nanoparticles into the HEMA monomer before they were polymerized. The resultant nanocomposite films were characterized by Fourier transform infrared (FT-IR) and the vibrating sample magnetometer (VSM). The swelling behavies and the hemolytic ratios of the filmes were also investigated in this work.The equilibrium swelling ratio decreased with the increase of the amount of nanoparticles. The nanocomposite films had a clear superparamagnetic behavior because of the addition of nanoparticles. The hemolytic ratios were all lower than 5%, which indicated that the nanocomposites films had the good blood compatibility and can be used in the biomedical field

Abstract: Intervertebral disc (IVD) damage due to degeneration, trauma or inflammation is the main cause for lower back pain leading to morbidity and loss of function of the spinal column. Until recently the state of the art treatment for degenerative disc disease (DDD) was arthrodesis. Developments in vertebral arthroplasty enable degenerated disc to be replaced with prosthetic IVD devices while maintaining motion at the affected part. The ability of the intervertebral device to support the in vivo loading environment is critical for the clinical success of such devices. However, such properties are depended on the location and structure of IVD, as the mechanical properties of IVD change locally [1]. The objective of this study was to evaluate the in vivo tissue compatibility of a novel composite, made with poly 2-hydroxyethyl methacrylate (pHEMA), poly ε-caprolactone (PCL) and poly ethylene terephthalate (PET) in an animal model. In vivo qualitative and quantitative results at 6 weeks post intraosseous implantation in rabbit femur revealed that this hydrogel, in contact with bone tissue, showed no tissue damage at the implant-bone interface. This novel composite disc prosthetic material is biocompatible as bone growth was observed into the implant and there was no evidence of toxicity to bone or inflammatory responses at the peri-implant tissue.

Abstract: To replace a poly(2-hydroxyethyl methacrylate) (PHEMA) sponge, which has limited applications as an implant material, PHEMA and poly(2-hydroxyethyl methacrylate-co-sodium methacrylate) (P(HEMA-co-SMA)) hydrogels with enhanced biocompatibility were prepared based on the copolymerization of 2-hydroxyethyl methacrylate (HEMA) and sodium methacrylate (SMA) at a high monomer concentration. When the cytotoxicity, cell adhesion, and in vivo tissue reaction of the resulting hydrogels were investigated, the results suggest that hydrogels prepared by the copolymerization of HEMA and SMA at a high monomer concentration have great potential as implant materials with an excellent biocompatibility.