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A Scalable and Cycle Process for 2,4-Dibromopyrimidine

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Abstract:

A scalable and cycle process for 2,4-dibromopyrimidine is developed by bromination of 2,4-dichloropyrimidine using phosphorus tribromide. Compared with the literature reported before, the amount of bromination agent-phosphorus tribromide has been greatly reduced and purification of the product by recrystallization is realized. The total yield of 2,4-dibromopyrimidine can reach to 85.4%. The process is more suitable for scale-up production.

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Periodical:

Advanced Materials Research (Volumes 955-959)

Pages:

694-697

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.955-959.694

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Online since:

June 2014

Authors:

Yue Zhang, Ting Ting Liu, Yi Feng Yu, Man Du, Shi Xia Xu, Hai Wen Song, Hong Xia Du

Keywords:

4-Dibromopyrimidine, 4-Dichloropyrimidine, Bromination, Phosphorus Tribromide

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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