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Natural Bovine Anorganic Apatite and Collagen Presents Osteoconductivity and Contribute to Bone Repair of Rat Calvaria Critical Size Defect

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Abstract:

The aim of this study was verify the biological efficacy of the use of a xenograft for bone loss therapy. Blood clot, particulate autogenous bone or anorganic bovine xenograft filled critical size defects (CSD) in rat calvaria (8mm diameter). After 0, 7, 30 and 90 days the animals were killed and macroscopic, radiographic and histopathological analysis were conducted. Although no treatment promoted the total closure of bone defect, autogenous bone group had better bone repair after 90 days, followed by xenograft group that exhibited direct bone neoformation onto, and around, the particles confirming its osteoconductivity. In conclusion, the xenograft tested in vivo showed biocompatibility, biodegradability and osteoconductive properties in rat calvaria CSD.

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Periodical:

Key Engineering Materials (Volumes 396-398)

Pages:

249-252

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.396-398.249

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Online since:

October 2008

Authors:

I.I.C. Silva, S. Pimentel-Soares, Rafael C. Bittencourt, José Mauro Granjeiro

Keywords:

Apatite, Bone Repair, Collagen, Critical Size Defect, Xenograft

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© 2009 Trans Tech Publications Ltd. All Rights Reserved

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