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Fabrication of Porous n-HA/PA66 Composite for Bone Repair
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Characterization and Antibacterial Effect of a Novel Nanocomposite Membrane
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Development of Poly(Vinyl Alcohol)-Collagen-Hydroxyapatite Nanohybrids for Tissue Grafting
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Development of Poly(Vinyl Alcohol)-Collagen-Hydroxyapatite Nanohybrids for Tissue Grafting

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Abstract:

Poly(vinyl alcohol) (PVA) was introduced during in situ synthesis of hydroxyapatite (HA) in neutral collagen (COL) solution and final PVA-COL-HA nanohybrids were achieved via sequential steps including gelation by fibrillogenesis, freezing-thawing physical crosslinking, removal of unreacted residues and dehydration. This method is expected to endow the pure PVA with good bioactivity and meanwhile the presence of elastic PVA would improve the properties of COL-HA composites. The phase, microstructure and possible molecular interactions of the achieved PVA-COL-HA nanohybrids were analyzed by using X-ray diffraction, Fourier transform infra-red spectroscopy and scanning electron microscopy. The results indicate that the inorganic phase is poorly crystallized apatite with a nanometer size due to the confinement of organic macromolecules which forms a network structure.

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Periodical:

Key Engineering Materials (Volumes 330-332)

Pages:

329-332

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.330-332.329

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Online since:

February 2007

Authors:

Xiao Min Wang, Xu Dong Li, Gui Qiu Zheng, Xiao Liang Wang, Xing Dong Zhang, Zhong Wei Gu

Keywords:

Collagen, Hydroxyapatite (HAP), In Situ Synthesis, Nanohybrid, Poly(vinyl alcohol)

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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References

[1] R. Murugan, S. Ramakrishna: Composites Science and Technology Vol. 65(2005), p.2385.

Google Scholar

[2] M.K. Yusuf, S.K. Dhirendra and T.L. Cato: J. Biomed. Mater. Res. Vol. 69A (2004), p.728.

Google Scholar

[3] M. Kikuchi, T. Ikoma, S. Itoh, H. N. Matsumoto, Y. Koyama, K. Takakuda, K. Shinomiya and J. Tanaka: Compo. Sci. Tech. Vol. 64(2004), p.819.

Google Scholar

[4] W. Zhang, Z. L. Huang: J. Am. Ceram. Soc. Vol. 86(2003), p.1052.

Google Scholar

[5] Z.Q. Gu, J.M. Xiao and X.H. Zhang: Bio-Med. Mat. Engi. Vol. 8(1998), pp.75-81.

Google Scholar

[6] H. Kobayashi, M. Kato, T. Ikoma and J. Tanaka: Mater. Sci. Engi. Vol. 24(2004), p.729.

Google Scholar

[7] S. Nayer, A. Sinha: Collo. Surf. B: Biointerfaces. Vol. 35(2004), p.29.

Google Scholar

[8] X. D. Li, X. M. Wang, X. Y. Lin, J. M. Jiang, X. D. Zhang. Key Engin. Mater. Vol. 309-311(2005), p.1185.

Google Scholar

[9] X.M. Wang, X.D. Li, G.Q. Zheng, J.M. Jiang, J.Y. Chen, X. D. Zhang. Key Engin. Mater. Vol. 309-311(2005), p.1165.

Google Scholar

[10] S. Koutsopoulos. J. Biomed. Mater. Res. Vol. 62 ( 2002). p . 600 Figure 3 SEM image of cross-section of PVA-COL-HA.

Google Scholar