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Preparation and Cytocompatibility of Novel Nano-HA/PLA Composite

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Abstract:

In order to prepare nano-hydroxyapatite/poly(lactide) (n-HA/PLA) composite with good interfacial interaction, some groups which could bind with Ca ions in HA crystals need to be introduced onto PLA surface. Poly(α-methacrylic acid) (PMAA) was grafted on the PLA surfaces via photooxidization and subsequent UV induced polymerization. Suspension of PMAA-PLA microparticles with an average size as 133.1nm was prepared with solvent evaporation technique. Then utilizing the action of template manipulating of PMAA-PLA microparticles, n-HA/PLA composite were synthesized. Zeta potentials measurement and SEM indicated that there were good interfacial interactions between two phases of n-HA/PLA composite. The results of cell viability confirmed that n-HA/PLA composite possessed good cytocompatibility, so the n-HA/PLA composite scaffold obtained by electrospun technology might be used as bone tissue engineering scaffold.

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Periodical:

Key Engineering Materials (Volumes 330-332)

Pages:

369-372

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.330-332.369

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Online since:

February 2007

Authors:

Wen Qian Xiao, Yu Mei Xiao, Xian Tao Wen, Hong Song Fan, Xing Dong Zhang

Keywords:

Composite, Cytocompatibility, Interfacial Interaction, Nano-Hydroxyapatite, Poly(lactide)

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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