Preparation of Calcium Carbonate / Poly(Lactic Acid) Composite Membranes Containing Mercapto Groups

Shingo Tokuda; Akiko Obata; Toshihiro Kasuga

doi:10.4028/www.scientific.net/KEM.330-332.487

Paper Titles

Synthesis and Characterization of n-HA/PVA/Gel Composite
p.471

Bioactive Hydroxyapatite/ Polyvinyl Alcohol Composite for Repair and Regeneration of Articular Cartilage
p.475

DCPD/Collagen Scaffold and Apatite Formation In Vitro
p.479

A Study of Bone-Like Apatite Formation on β-TCP/PLLA Scaffold in Static and Dynamic Simulated Body Fluid
p.483

Preparation of Calcium Carbonate / Poly(Lactic Acid) Composite Membranes Containing Mercapto Groups
p.487

Preparation and Characterization of Porous β-TCP/PLLA Composites with High β-TCP Content
p.491

Influence of Collagen Status on Microstructures of Porous Collagen/TCP Composites
p.495

Preparation and Characteristics of Strontium Containing Bioactive CaSiO₃ Ceramics
p.499

Three-Dimensional Characterization of the Microstructure of Bioglass/Polyethylene Composite by X-Ray Microtomography
p.503

HomeKey Engineering MaterialsKey Engineering Materials Vols. 330-332Preparation of Calcium Carbonate / Poly(Lactic...

Preparation of Calcium Carbonate / Poly(Lactic Acid) Composite Membranes Containing Mercapto Groups

Abstract:

Mercapto group controls the adsorption and release of insulin, which is one of the proteins for enhancing the osteoblast proliferation. Silicon-ion-species were reported to stimulate the bone-forming ability of osteoblasts. The present paper describes doping with mercapto groups and silicon-ion-species in a calcium carbonate/poly (lactic acid) composite membrane, which is prepared by a sol-gel method using 3-mercaptopropyltrimethoxysilane. The membrane was amorphous and showed high flexibility. A quantitative analysis by thiol-disulfide exchange reaction using 2, 2-dipyridyl disulfide reagent showed that the amount of mercapto group existing on membrane surface was estimated to be about 5.51μmol/cm2. A trace amount of silicon-ion-species was released from the membrane after soaking in tris (hydroxymethyl) aminomethane buffer solution at 37 oC. The membrane is expected to have high bone-forming ability.