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Covalent Immobilization of Heparin on Anatase TiO2 Films via Chemical Adsorbent Phosphoric Acid Interface

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Abstract:

Heparin is covalently immobilized onto the surface of anatase TiO2 film using the bifunctional linking reagent, APTES (3-Aminopropyltriethoxylsilane), which can be bonded to the film by reaction between ethoxyl of the linking reagent and hydroxyl of the film. Compared to the control, the immobilization is enhanced by phosphoric acid chemical pre-adsorption on the film for there is more hydroxyl group present. Platelets deposited to heparinized surface showed only minor spreading and aggregation. The results of this study suggest that heparin immobilization to anatase TiO2 films via phosphoric acid interface may improve the in vivo blood compatibility.

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Periodical:

Key Engineering Materials (Volumes 330-332)

Pages:

865-868

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.330-332.865

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Online since:

February 2007

Authors:

Ya Jun Weng, Ruixia Hou, Dong Xie, Jin Wang, Nan Huang

Keywords:

Anatase, APTES, Heparin, Immobilisation, Phosphoric Acid

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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References

[1] X.H. Wang, D.P. Li, W.J. Wang: International Journal of Biological Macromolecules Vol. 33 (2003), P. 95.

Google Scholar

[2] A.P. Zhu, M. Zhang, J. Wu: Biomaterials Vol. 23 (2002), P. 4657.

Google Scholar

[3] Y. J. Kim, I.K. Kang, M. W. Huh: Biomaterials Vol. 21 (2000), P. 121.

Google Scholar

[4] W.W. Zhang, X.M. Ren, H.F. Li: Journal of Colloid and Interface Science Vol. 255 (2002), P. 150.

Google Scholar

[5] Q. Liu, J. Ding, F.K. Mante: Biomaterials Vol. 23 (2002), P. 3103.

Google Scholar

[6] G. Shen, A. Horgan, R. Levicky: Colloids and Surfaces B: Biointerfaces Vol. 35 (2004), P. 59.

Google Scholar

[7] W.P. Qian, B. Xu, L. Wu: J. Colloid and Interface Science Vol. 214 (1999), P. 16.

Google Scholar

[8] A. Simon, T. C. Bouhacina, M.C. Port: J. Colloid and Interface Science Vol. 251 (2002), P. 278.

Google Scholar

[9] C.R. Suri, G.C. Mishra: Biosensor & Bioelectronics Vol. 11 (1996), P. 1199.

Google Scholar

[10] E. S. Gawalt, M. J. Avaltroni, M. P. Danahy: Langmuir Vol. 19 (2003), P. 200.

Google Scholar

[11] I.K. Kang, O.H. Kwon, Y.M. Lee: Biomaterials Vol. 17 (1996), P. 841 Fig. 7 SEM images of samples after being contacting with PRP for 4h (a) anatase TiO2 film, (b) ASH, (c) APSH, x3000.

Google Scholar