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A Novel Polycaprolactone/Hydroxyapatite Scaffold for Bone Tissue Engineering
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Evaluation of Semi-Interpenetrating Polymer Networks Composed of Chitosan and Poloxamer for Artificial Skin
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Effects of Mechanical Stress on the In Vitro Degradation of Porous Composite Scaffold for Bone Tissue Engineering
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Bone Regeneration Materials
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Bone Regeneration Materials

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Abstract:

Biomaterials Center is composed of five groups and collaborate each other to examine interdisciplinary fields of biomaterials. In the ceramics-based biomaterials research, we have been developing three novel bone regeneration materials, i.e., high-porosity hydroxyapatite (HAp) ceramics with high-strength, guided bone regeneration (GBR) membranes and bone-like nanocomposite composed of HAp and collagen. The GBR membrane composed of β-tricalcium phosphate and biodegradable copolymer of lactide, glycolide and ε-caprolactone has thermoplastic, pH auto-adjustment and enough mechanical property to protect an invasion of surrounding tissues. With the membrane, bone defect up to 20 × 10 × 10 mm3 in length in mandibles and segmental bone defect up to 20 mm in length in tibiae of beagles are regenerated without any additional bone fillers or cell transplantations. The bone-like nanocomposite is synthesized by a co-precipitation of HAp and collagen via their self-organization. The dense composite has a half to quarter mechanical strength (40 MPa) to cortical bone and the porous one demonstrates sponge-like viscoelasticity. The composites implanted into bone are incorporated into bone remodeling metabolism like as autogenous bone graft, i.e., they are resorbed by osteolasts followed by osteogenesis by osteoblasts.

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Advanced Biomaterials VII View Preview

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Periodical:

Key Engineering Materials (Volumes 342-343)

Pages:

277-280

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.342-343.277

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Online since:

July 2007

Authors:

Masanori Kikuchi, M. Tanaka

Keywords:

Biodegradable Polymer, Bone Remodeling Process, Collagen, Guided Bone Regeneration GBR, Hydroxyapatite (HAP), Nanocomposite, Tricalcium Phosphate

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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References

[1] M. Kikuchi, Y. Suetsugu, J. Tanaka and M. Akao, J. Mater. Sci.: Mater. in Med. 8 (1997), p.361.

Google Scholar

[2] M. Kikuchi, J. Tanaka, Y. Koyama and K. Takakuda, J. Biomed. Mater. Res. (Appl. Biomater. ), 48 (1999), p.108.

Google Scholar

[3] M. Kikuchi and J. Tanaka, J. Ceram. Soc. Japan, 108 (2000), p.642.

Google Scholar

[4] M. Kikuchi, Y. Koyama, K. Takakuda, H. Miyairi, N. Shirahama and J. Tanaka, J. Biomed. Mater. Res., 62 (2002), p.265.

Google Scholar

[5] Y. Koyama, M. Kikuchi, T. Yamada, T. Kanaya, H.N. Matsumoto, K. Takakuda, H. Miyairi and J. Tanaka, JSME International J., 46 series C (2003), p.1409.

DOI: 10.1299/jsmec.46.1409

Google Scholar

[6] M. Kikuchi, Y. Koyama, T. Yamada, Y. Imamura, T. Okada, N. Shirahama, K. Akita, K. Takakuda and J. Tanaka, Biomaterials, 25 (2004), p.5979.

DOI: 10.1016/j.biomaterials.2004.02.001

Google Scholar

[7] M. Kikuchi, S. Itoh, S. Ichinose, K. Shinomiya and J. Tanaka: Biomater. Vol. 22 (2001), p.1705.

Google Scholar

[8] M. Kikuchi, H.N. Matsumoto, T. Yamada, Y. Koyama, K. Takakuda and J. Tanaka: Biomater. Vol. 25 (2004), p.63.

Google Scholar

[9] M. Kikuchi, T. Ikoma, S. Itoh, H.N. Matsumoto, Y. Koyama, K. Takakuda, K. Shinomiya and J. Tanaka: Composite Sci. and Tech., Vol. 64, (2004), p.819.

Google Scholar

[10] M. Kikuchi, S. Itoh, H.N. Matsumoto, Y. Koyama, K. Takakuda, K. Shinomiya, and J. Tanaka: Key-Eng Mater. Vol. 240-242 (2003), p.567.

DOI: 10.4028/www.scientific.net/kem.240-242.567

Google Scholar

[11] M. Kikuchi, T. Ikoma, D. Syoji, H.N. Matsumoto, Y. Koyama, S. Itoh, K. Takakuda, K. Shinomiya and J. Tanaka: Key-Eng Mater. Vol. 254-256 (2004), p.561.

DOI: 10.4028/www.scientific.net/kem.254-256.561

Google Scholar

[12] S. Itoh, M. Kikuchi, K. Takakuda, Y. Koyama, H.N. Matsumoto S. Ichinose, J. Tanaka, T. Kawauchi and K. Shinomiya: J. Biomed. Mater. Res. Vol. 54 (2001), p.445.

DOI: 10.1002/1097-4636(20010305)54:3<445::aid-jbm190>3.0.co;2-9

Google Scholar

[13] S. Itoh, M. Kikuchi, Y. Koyama, K. Takakuda, K. Shinomiya and J. Tanaka: Biomater. Vol. 23 (2002), p.3919.

Google Scholar

[14] S. Itoh, M. Kikuchi, K. Takakuda, K. Nagaoka, Y. Koyama, J. Tanaka and K. Shinomiya: J Biomed. Mater. Res. Vol. 63 (2002), p.507.

DOI: 10.1002/jbm.10305

Google Scholar

[15] S. Itoh, M. Kikuchi, Y. Koyama, K. Takakuda, K. Shinomiya and J. Tanaka: Cell Transplant. Vol. 13 (2004), p.451.

DOI: 10.3727/000000004783983774

Google Scholar