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Thiolated Eudragit-Coated Chitosan Microspheres as an Oral Drug Delivery System

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Abstract:

The aim of this study is to prepare mucoadhesive chitosan microspheres for protein drug to deliver to intestine through oral administration. The thiolated Eudragit was synthesized by reaction between L-cysteine hydrochloride and Eudragit® L-100. About 8 mol-% of cysteine was introduced to the Eudragit-cysteine conjugate. The conjugate was used to coat bovine serum albumin (BSA)-loaded chitosan microspheres. The average particle sizes of BSA-loaded thiolated Eudragit-coated chitsoan microspheres (TECMs) were 4.06±0.74 .m and the uniform sizedistribution was shown. The in vitro release of BSA from BSA-loaded TECMs was pH-dependent. Our results indicated that thiolated Eudragit might be a good candidate as a coating material for oral delivery of protein drug owing to mucoadhesive and pH-sensitive properties.

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Periodical:

Key Engineering Materials (Volumes 342-343)

Pages:

445-448

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.342-343.445

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Online since:

July 2007

Authors:

Ji Shan Quan, Hu Lin Jiang, Yun Jaie Choi, Mi Kyong Yoo, Chong Su Cho

Keywords:

Bovine Serum Albumin (BSA), Chitosan Microspheres, Mucoadhesion, Oral Drug Delivery System, Thiolated Eudragit®L-100

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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