Paper Titles
Preparation of Porous Poly (L-Lactic Acid) (PLLA) Scaffold by Porogen Leaching and Freeze Drying
p.381
Fabrication and Characterization of Mechanically Reinforced Collagen Sponge
p.385
Corneal Implantation with Collagen-Copolymer Matrices
p.389
In Vitro and In Vivo Evaluation of Amino Acid-Functionalized Cellulose Beads for Whole Blood Hemoperfusion
p.393
In Vitro Degradation of Medical Polyacrylamide Hydrogel I.Oxidation
p.397
Biological Behaviors of Keratinocytes Cultured on Chitosan-Gelatin Membrane
p.401
Determination of Residual Acrylamide Monomer in Medical Polyacrylamide Hydrogel by HPLC-SPE
p.405
Osteoblast Differentiation and Apatite Formation on Gamma-Irradiated PLLA Sheets
p.409
Removed due to copyright infringements.
p.413

In Vitro Degradation of Medical Polyacrylamide Hydrogel I.Oxidation

Article Preview

Abstract:

Polyacrylamide (PAM) was usually atoxic, stable. Its hydrogel (PAMG) has been used in plastic and aesthetic surgery more than 10 years in P.R.China, Ukraine and Russia. But there were some complications with PAMG injected in patients. Considering the complicacy in vivo, it was necessary to study the PAMG’s stability. In this paper, H2O2 was added in PAMG in vitro and acrylamide (AM) content after oxidating was determined using HPLC method. Detection limit for AM can be achieved in the parts-per-billion rang. The AM content in supernatant at 0.5, 1,2 and 3 hr after oxidating of PAMG was 1.27e-8g/ml, 1.35e-8g/ml, 1.03e-7g/ml and 2.74e-7g/ml, respectively. The AM content in supernatant of PAMG was 7.70e-9g/ml. These results indicated that PAMG can be degraded to AM by hydroxyl radical. Under the same condition, the AM content was stable. So, AM can exist for a while when it was produce by degrading of PAMG. That can increase the toxicity of PAMG.

You might also be interested in these eBooks
Advanced Biomaterials VI View Preview

Info:

Periodical:

Key Engineering Materials (Volumes 288-289)

Pages:

397-400

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.288-289.397

Citation:

Cite this paper

Online since:

June 2005

Authors:

Zi Yi Wan, Ting Fei Xi, P. Zhao, Cheng Xiang Fan, Y. Sun, Z.G. Feng

Keywords:

Acrylamide, Degradation, High Performance Liquid Chromatography (HPLC), Oxidation, Polyacrylamide

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2005 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

References

[1] L. M. Ver Vers: Journal of Chromatographic Science. Vol 37: 486-494, (1999).

Google Scholar

[2] M.H. Yang: Polymer Testing. 17: 191-198, (1998).

Google Scholar

[3] E.A. Smith: Ecotoxicology and Environmental safety, 35: 121-135, (1996).

Google Scholar

[4] L.Y. Zhu: Polymer Materials Science and Engineering. Vol. 16(1): 113-116, (2000).

Google Scholar

[5] Z. Sroka: Food and Chemical Toxicology. Vol. 41(6): 753-758, (2003).

Google Scholar