Study on Preparation and Property of Drug Loading of AZM-PCL Nanoparticels

Li Li Ruan; Da Xin Wang; You Wei Zhang; Jiong Xin Zhao; Min Wu Wang; Xiu Fang Zhang; Nan Liang Chen

doi:10.4028/www.scientific.net/AMM.121-126.1764

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vols. 121-126Study on Preparation and Property of Drug Loading...

Study on Preparation and Property of Drug Loading of AZM-PCL Nanoparticels

Abstract:

This study was to prepare polycaprolactone (PCL) nanoparticles. The biodegradable PCL was used as the carrier, and Azithromycin (AZM) was used as the model drug. AZM-PCL nanoparticles (AZM-PCL-NPS) were prepared by desolvation method. The effect of preparation condition: concentration of PCL, molecular weight of PCL, organic solvents, dosage ratio and so on, were specially noted and compared. A homogeneous size distribution and good dispersion were observed, the average diameter was around 70~400 nm, and the distribution index was 0.036~0.136. The drug loading reached 27.69 %, and the efficiency of encapsulation reached as high as 93.25%. The results were better than the other similar researches, this preparation way was successful.

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Periodical:

Applied Mechanics and Materials (Volumes 121-126)

Pages:

1764-1768

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.121-126.1764

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Online since:

October 2011

Authors:

Li Li Ruan, Da Xin Wang, You Wei Zhang, Jiong Xin Zhao, Min Wu Wang, Xiu Fang Zhang, Nan Liang Chen

Keywords:

AZM-PCL Nanoparticel, Desolvation Method, Property of Drug Loading

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