Study on Preparation and Property of Drug Loading of AZM-PCL Nanoparticels

Abstract:

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This study was to prepare polycaprolactone (PCL) nanoparticles. The biodegradable PCL was used as the carrier, and Azithromycin (AZM) was used as the model drug. AZM-PCL nanoparticles (AZM-PCL-NPS) were prepared by desolvation method. The effect of preparation condition: concentration of PCL, molecular weight of PCL, organic solvents, dosage ratio and so on, were specially noted and compared. A homogeneous size distribution and good dispersion were observed, the average diameter was around 70~400 nm, and the distribution index was 0.036~0.136. The drug loading reached 27.69 %, and the efficiency of encapsulation reached as high as 93.25%. The results were better than the other similar researches, this preparation way was successful.

Info:

Periodical:

Edited by:

Dongye Sun, Wen-Pei Sung and Ran Chen

Pages:

1764-1768

DOI:

10.4028/www.scientific.net/AMM.121-126.1764

Citation:

L. L. Ruan et al., "Study on Preparation and Property of Drug Loading of AZM-PCL Nanoparticels", Applied Mechanics and Materials, Vols. 121-126, pp. 1764-1768, 2012

Online since:

October 2011

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Price:

$35.00

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