In order to cope with the pressure from competition of global marketization, it’s common for enterprises to carry out multiple projects at the same time. The following has always been the focus and key issues for management wanting to achieve greater operational benefits when carrying out multiple projects simultaneously 1. resource allocation 2. shorten project-development cycle by coordinating relationships between team members 3. lower operating cost This paper covers 4. Introducing the concept of Multi-Project Management and its difference from general project management 5. Analyze the advantages and existing problems of Multi-Project Management 6. Address the issues such as resource allocation and conflicts resolution/coordination between project manager & operation manager by using Quantitative Analysis such as Game theory 7. Provide theory reference and practical suggestions for entrepreneurs.