Finite Element Analysis of Pharmaceutical Tablet Compaction

Abstract:

A finite element simulation of convex tablet compaction was present in this paper with Drucker–Prager Cap model of lactose material. The effects of different compression speed on tablet property were analysis. The results show that the maximum stress appears the top and bottom near the die and the mises stress distribution become more uniform with the speed decreased. The density distribution change little with the variation of compression speed and the maximum density locate the top and bottom near the die rim. The compression speeds have little affected on the powder displacement. The research can contribute to save cost for tablet production test through the simulation analyze the tablet property of compression process.

• Periodical: Applied Mechanics and Materials (Volumes 217-219)
• Pages: 2117-2120
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.217-219.2117
• Online since: November 2012
• Authors: Guo Ning Si, Lan Chen
• Keywords: Convex Tablet, Drucker–Prager Cap Model, Finite Element Analysis (FEA)

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