Evaluation of Surface Roughness Variations of Solid Dosage Forms in Simulated Physiological Conditions

Abstract:

Rehabilitation of joints that underwent major surgery, involves reducing postoperative pain and inflammation. Many pharmaceutical product used in reducing joint pain are based on the extended-release technology and becoming increasingly important in research domain. The performance of extended-release matrix tablets is dependent on the solid dosage properties like matrix materials used, which are semi-synthetic polymer like hydroxypropyl methylcellulose (HPMC) and sodium carboxy methylcellulose (Na CMC). Depending on the properties of the polymer used, drug release from the tablets may be controlled by erosion mechanism and surface roughness. In a physiological environment, the release of drug from a solid dosage form requires a gradual erosion of solid shape with simultaneous change of surface roughness. This paper presents the influence of surface erosion of solid dosage forms on the surface roughness and the release of the analgesic and anti-inflammatory substances in a biological environment similar to the human digestive juice.

• Periodical: Applied Mechanics and Materials (Volume 245)
• Pages: 68-73
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.245.68
• Online since: December 2012
• Authors: Monica Cretan Stamate, Carmen Gafitanu, Ciprian Stamate, Eliza Gafitanu
• Keywords: Drug Release, Erosion, Solid Dosage Forms, Surface Roughness (SR)

References

[1] Y. Qiu, G. Zhang: Research and development aspects of oral controlled release dosage forms. In: Handbook of Pharmaceutical Controlled Release Technology, Ed. DL Wise, Marcel Dekker Inc., New York, NY, USA (2000) 465- 503.

DOI: 10.1201/9781482289985-28

[2] E. Sundy, MP. Danckwerts: A novel compression-coated doughnut-shaped tablet design for zero-order sustained release. Eur J Pharm Sci 22 (2004) 477-485.

DOI: 10.1016/j.ejps.2004.05.004

[3] SS. Bansal, AM. Kaushal, AK. Bansal: Molecular and thermodynamic aspects of solubility advantage from solid dispersions. Mol Pharm 4 (2007) 794-802.

DOI: 10.1021/mp7000796

[4] Romanian Pharmacopoeia X edition, Ed Medicala, Bucuresti, 1993.

[5] The United States Pharmacopoeia XXIII edition, United States Pharmacopoeia Convention, Inc., Rockville, 1995.

[6] Taylor Hobson: Form Talysurf Intra Operator's Handbook, England, 2002.