Computational Simulation on the Material Basis of Sini Decoction in Treating Coronary Heart Disease

Abstract:

Sini Decoction is a powerful prescription which has a curative effect. Its significant effect had been attracted by the ancient medical attention. In order to provide better services in health care and provide better clinical efficacy, it is necessary to reveal the pharmacodynamic material basis of Sini Decoction for certain disease. We conducted computational simulation of Sini Decoction in treating coronary heart disease based on computational chemistry to reveal treatment mechanism and pharmacodynamic material basis. The results show that Sini Decoction’s effect on coronary heart disease is based on the active ingredient groups. Hundreds of small molecules act upon coronary heart disease associated with different targets, this makes the coronary heart disease accept systematic, comprehensive prevention and treatment.

• Periodical: Applied Mechanics and Materials (Volumes 278-280)
• Pages: 535-538
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.278-280.535
• Online since: January 2013
• Authors: Wei Ye Tao, Ning Wang, Qi Rui Zhang, Mao Sheng Huang
• Keywords: Computational Simulation, Molecular Docking, Sini Decoction, Virtual Screening

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