In most cases, high gas concentration and oxygen consumption result in severe hypoxia after explosion. When the ventilation system is damaged, the air volume will be re-distributed so that explosion region is lack of oxygen. However, under mechanical ventilation and self-diffusion, the high temperature and toxic and harmful gases will constantly spread downwind of the roadway or certain areas, which threatens substations, winch room and workers’ escape. If the hot gas meets with gas concentration overrun areas or the coal dust explosion hazardous area, secondary disasters such as fire or explosion may be caused. Numerical simulation shows that high temperature, toxic and harmful gas will be disseminated. In conclusion, measures must be taken to withdraw the workers and to restore ventilation to prevent secondary disasters. If the gas explosion power is increased, the safety nearby working face would be threatened. To control and reduce the extent of gas explosion hazards and losses, a reasonable gas explosion disaster prevention and treatment plan should be established.