When vehicles run on road, they will be overtaken, cross by other vehicles or be impacted by crosswind. The other events of overtaking and in crosswind were investigated more deeply. A few of paper report the state of the research on this problem. Until now there are no any wind tunnel and road tests to study on road vehicle aerodynamics while crossing each other. Some numerical simulations were carried out by adopting technology of sliding interface and moving mesh. The method of numerical simulations was narrated in detail. The transient process of vehicles crossing each other was realized. Then the trends of aerodynamic coefficients changing were obtained from the flow field of simulation results. The quantificational changing of vehicles aerodynamic coefficients was obtained when they cross each other. The vehicles are sedan and coach. The simulation results indicated that the all aerodynamic coefficients of two vehicles changed large. The aerodynamic force was important to the vehicles’ handling stability when they cross each other.