Mathematical Modelling for the Quality Evaluation of Baikal Skullcap Root

Abstract:

In this paper, a model for evaluating the quality of Baikal skullcap root based on the chromatographic fingerprint and pharmacological effect correlation mode was established by using multivariate polynomial fitting technique. This result is new and the accuracy of the model is tested by comparing the modeled results with the experimental data. In addition, a related piece of software was developed. This paper also provides us with a new modelling method for the quality evaluation of traditional Chinese herbal medicine.

• Periodical: Applied Mechanics and Materials (Volumes 40-41)
• Pages: 167-173
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.40-41.167
• Online since: November 2010
• Authors: Ke Li, Wei Cheng, Xiao Jian Liu, Shu Bin Li, En Guang Hou, Yan Gao, Liang Wang, Qing Liu, Bo Nian Zhao, Zong Yuan Yu
• Keywords: Baikal Skullcap Root, Chromatographic Fingerprint and Pharmacological Effect Correlation Mode, Multivariate Polynomial Fitting, Quality Evaluation

References

[1] G. Alaerts, N. Matthijs, J. Smeyers-Verbeke, and Y. Vander Heyden: Chromatographic fingerprint Development for Herbal Extracts: A Screening and Optimization Methodology on Monolithic Columns, J. Chromatogr. A, Vol. 1172 (2007), p.1–8.

DOI: 10.1016/j.chroma.2007.07.080

[2] P. Chen, M. Ozcan, and J. Harnly: Chromatographic Fingerprint Analysis for Evaluation of Ginkgo biloba Products, Anal. Bioanal. Chem., Vol. 389 (2007), p.251–261.

DOI: 10.1007/s00216-007-1386-9

[3] F. Gan, and R. Y. Ye: New Approach on Similarity Analysis of Chromatographic Fingerprint of Herbal Medicine, J. Chromatogr. A, Vol. 1104 (2006), p.100–105.

DOI: 10.1016/j.chroma.2005.11.099

[4] W. Jin, R. L. Ge, Q. J. Wei, T. Y. Bao, H. M. Shi, and P. F. Tu: Development of High Performance Liquid Chromatographic Fingerprint for the Quality Control of Rheum Tanguticum Maxim. ex Balf., J. Chromatogr. A, Vol. 1132 (2006), p.320–324.

DOI: 10.1016/j.chroma.2006.08.022

[5] H. Z. Lian, and Y. N. Wei: Chromatographic Fingerprints of Industrial Toluic Acids Established for Their Quality Control, Talanta, Vol. 71 (2007), p.264–269.

DOI: 10.1016/j.talanta.2006.03.054

[6] A. Sirikatitham, T. Chuchom, and A. Itharat: Development of the Chromatographic Fingerprint Analysis of Dioscorealides and Dioscore-anone from Dioscorea Membranacea Pierre, Songklanakarin J. Sci. Technol., Vol. 29 (2007): Thai Herbs II, p.101–107.

[7] P. S. Xie, S. B. Chen, Y. Z. Liang, X. H. Wang, R. T. Tian, and R. Upton: Chromatographic Fingerprint Analysis—A Rational Approach for Quality Assessment of Traditional Chinese Herbal Medicine, J. Chromatogr. A, Vol. 1112 (2006), p.171–180.

DOI: 10.1016/j.chroma.2005.12.091

[8] L. H. Zhao, C. Y. Huang, Z. Shan, B. R. Xiang, and L. H. Mei: Fingerprint Analysis of Psoralea Corylifolia L. by HPLC and LC– MS, J. Chromatogr. B, Vol. 821 (2005), p.67–74.

DOI: 10.1016/j.jchromb.2005.04.008