In this paper, the prediction model of micro-milling cutters in milling process is established to simulate the wear depth in the software DEFORM-3D, the chips growing up an forming process. The paper studies the wear level during the cutting process of micro milling amount of feed per tooth and spindle speed. In this paper the cutting force, cutting heat flow and the contact situation between cutting tool and workpiece are considered in the simulation model. The paper uses abrasion mathematical model related to contact stress and temperature, etc. and studies the influence of the wear depth of milling cutter through the analysis of milling temperature and metal sliding characteristics. Finally, the FEA micro –soft ware is used to verify the change of amount of feed per tooth and the spindle speed with wear depth. The paper provides reasonable parameters for using the micro milling cutter better.