Preparation and Properties of Thermosensitive Poly(N-isopropylacrylamide-co-glycyrrhetinic acid) Microgels for Controlled Growth Factor Release

Yue Mei Zhao; Xiao Ling He; Jia Quan Li; Xiang Xu Li; Li Chen; Dong Sheng Wei

doi:10.4028/www.scientific.net/AMM.457-458.148

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vols. 457-458Preparation and Properties of Thermosensitive...

Preparation and Properties of Thermosensitive Poly(N-isopropylacrylamide-co-glycyrrhetinic acid) Microgels for Controlled Growth Factor Release

Abstract:

A series of poly (N-isopropylacrylamide-co-glycyrrhetinic acid) (P(NIPAAm-co-GA)) microgels were prepared by dispersion copolymerization. The morphologies of the microgels were observed by field scanning electron microscopy (FE-SEM) and transmission electron microscope (TEM). The temperature sensitivity of microgels was examined by measuring the optical transmittance of the microgel aqueous solution. Cytotoxicity of the microgels was investigated by MTT assay. The results indicated that microgel particles had a regular spherical shape of about 500 nm with narrow size distributions. Moreover, P(NIPAAm-co-GA) microgels exhibited good temperature sensitivity and low toxicity. This novel microgel could be expected as good candidate for controlled growth factor release.Intorduction

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Periodical:

Applied Mechanics and Materials (Volumes 457-458)

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148-151

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.457-458.148

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Online since:

October 2013

Authors:

Yue Mei Zhao, Xiao Ling He, Jia Quan Li, Xiang Xu Li, Li Chen, Dong Sheng Wei

Keywords:

Glycyrrhetinic Acid, Microgel, Poly(N-Isopropylacrylamide), Thermosensitive

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