Substrate Stiffness as a Regulator in Catalyzing Integrin-Mediated Cell Adhesion Nucleation: A Mechanochemical Model

Abstract:

We provide here a simplified mechanochemical model to describe the role of substrate stiffness in mediating the chemical reactions between integrins on cell membrane and ligands immobilized on the substrate. By taking into account the energy input for integrin activation on a compliant substrate, Our simulation shows that integrin activation and the downstream integrin clustering can be regulated by substrate stiffness in a value-dependent manner, which is consistent with previous experimental studies.

• Periodical: Applied Mechanics and Materials (Volume 459)
• Pages: 555-559
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.459.555
• Online since: October 2013
• Authors: Xiao Ling Peng
• Keywords: Cell Adhesion, Integrin Activation, Substrate Stiffness

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