Comprehensive Control of 7-Amino-Cephalsporanic Acid Dust in Drying Workshop

Abstract:

7-amino-cephalsporanic acid (7-ACA) is the key intermediate of cephalosporin, which has a strong sensitization and explosion hazard. So it seriously affects the worker’s health in the workshop, the environment safety out of the workshop and work safety. The drying workshop of 7-ACA at a pharmaceutical enterprise in Shijiazhuang is investigated and the production process is analyzed, the key places of dust leakage and the causes of dust generation are identified. Combined with the pollution and safety risk in drying workshop, the targeted control measures are taken from the process technology, ventilation system and dust collecting device, which effectively removed the adverse effects from 7-ACA leaking. The study provides a reference for the dust control in similar enterprises.

• Periodical: Applied Mechanics and Materials (Volumes 522-524)
• Pages: 481-484
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.522-524.481
• Online since: February 2014
• Authors: Jin Feng Zhang*, Xin Liu, Li Min Hou, Qin Liu
• Keywords: 7-ACA, Comprehensive Control, Dust Causes, Dust Collecting Device, Individual Protection, Ventilation System

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