Synthesis, Characterization and Property of Nano Rare Earth Terbium Complex with Gatifloxacin

Abstract:

Rare earth metal complexes have special characteristics, such as extremely narrow emission bands and high internal quantum efficiencies, which are suitable to be used as the emission materials, chemistry and biological technology. Ternary nano complex of terbium gatifloxacin phenanthroline was synthesized.The composition and structure of ternary complex were characterized by element analysis, Mass Spectrometry (MS), UltraViolet Absorption Spectrometry (UV) and fluorescence spectra(FS). The influences of solubility, thermal stability and luminescent properties of complex as well as addition of phenanthroline secondary ligands on the fluorescence spectra of the ternary complexes were studied. The results of fluorescence spectra analysis showed that partial energy was transferred from Characterization to terbium ions by intramolecular energy transfer processes, meanwhile, the addition of phenanthroline can effectively increase the luminescence intensity of terbium icons. The complex possessed well luminescence and showed characteristic emission peaks of Tb³⁺ under UV light excitation and emitted strong green fluorescence. Moreover, in an ITO/PVK/Tb(GFLX)₃Phen/Al device, Tb³⁺ ion can be excited by intramolecular ligand-to-metal energy transfer process. The main peak of emission at 545 nm is attributed to ⁵D₀→⁷F₂ transition of the Tb³⁺ ion, and this process results in the enhancing green emission. Biological actrivity properties of the rare earth complex was well studied.

• Periodical: Applied Mechanics and Materials (Volumes 541-542)
• Pages: 185-189
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.541-542.185
• Online since: March 2014
• Authors: Yu Guang Lv*, Li Zhang, Kui Lin Lv, Shu Jing Zhou, Du A, Ji Hui Zheng, Peng Jiao, Jia Yu Hou, Yui Zhu
• Keywords: Biological Actrivity, Characterization, Gatifloxacin, Luminescence Property, Nanorare Earth Complex

References

[1] Zhou S L, Yin C W, Wang H , Zhu X C, Yang G S, Wang S W. Synthesis, characterization, and catalytic activities of rare-earth metal complexes with iminopyrrolyl ligands  [J] Inorganic Chemistry Communications. 14(2011)1196-1200.

DOI: 10.1016/j.inoche.2011.04.015

[2] Xu M, Chen F J, Huang L , Xi P X, Zeng Z Z . Binding of rare earth metal complexes with an ofloxacin derivative to bovine serum albumin and its effect on the conformation of protein [J] Journal of Luminescence. 2011, 131, ( 8): 1557-1565.

DOI: 10.1016/j.jlumin.2011.03.025

[3] Changlun Tong，Xiajun Zhuo, Yun Guo, et al. Synchronous fluorescence determination of ciprofloxacin in the pharmaceutical formulation and human serum based on the perturbed luminescence of rare-earth ions. [J]Journal of Luminescence. 130(2010).

DOI: 10.1016/j.jlumin.2010.05.034

[4] N. Jime´nez-Garrido, L. Perello´, R. Ortiz el, Antibacterial studies, DNA oxidative cleavage, and crystal structures of Cu(II) and Co(II) complexes with two quinolone family members, ciprofloxacin and enoxacin[J] Journal of Inorganic Biochemistry. 99 (2005).

DOI: 10.1016/j.jinorgbio.2004.11.016

[5] M. N. Patel , M. R. Chhasatia, D. S. Gandhi. DNA-interaction and in vitro antimicrobial studies of some mixed-ligand complexes of cobalt(II) with fluoroquinolone antibacterial agent ciprofloxacin and some neutral bidentate ligand[J] Bioorganic & Medicinal Chemistry Letters. 19 (2009).

DOI: 10.1016/j.bmcl.2009.03.078

[6] Mohan N. Patel, Mehulsinh R. Chhasatia, Interaction of drug based binuclear mixed-ligand complexes with DNA [J] Bioorganic & Medicinal Chemistry. 17(2009) 5648–5655.

DOI: 10.1016/j.bmc.2009.06.023

[7] Alketa Tarushi, Eleni K. Efthimiadou, Petros Christofis, George Psomas. Neutral mononuclear dioxomolybdenum(VI) and dioxouranium(VI) complexes of oxolinic acid: Characteri -zation and biological evaluation[J] Inorganica Chimica Acta. 360 (2007).

DOI: 10.1016/j.ica.2007.05.041

[8] Dong-Rong Xiao, En-Bo Wang, Hai-Yan An. Rationally Designed, Polymeric, Extended Metal–Ciprofloxacin Com -plexes [J] Chem. Eur. J. 11(2005)6673 – 6686.

[9] Nan Zhang, Xiaoli Zhang, Yunfang Zhao . Voltammetric study of the interaction of ciprofloxacin–copper with nucleic acids and the determination of nucleic acids[J] Talanta. 62 (2004) 1041–1045.

DOI: 10.1016/j.talanta.2003.10.038

[10] S. M, Al-Ghannam. Atomic absorption spectroscopic, conductometric and colorimetric methods for determination of some fluoroquinolone antibacterials using ammonium reineckate [J] Spectrochim. Acta A. 69(2008)1188-1194.

DOI: 10.1016/j.saa.2007.06.023

[11] Yu Guang Lv, Chun Xiang Song, Yu Zhang, Jing Quan Sha, Cui Juan Liu, Fu Jun Zhang. Synthesis and electroluminescent property of ternary complexes Eu(TTA)3M [J] J Alloy Compd. 492(2010)259–263.

DOI: 10.1016/j.jallcom.2009.11.020