Investigation of Porosity Relationship in Additive Manufactured Novel Bone Scaffold

Abstract:

Additive manufacturing (AM) is one the advanced process for building up a component layer by layer, with one layer of material was bonded to the previously laid layer using a 3D design data. In the field of medical science AM is very much useful in the development of Bone Scaffolds. The bone scaffold needs the good level of porosity for the cultivation of cells. In this work, an algorithm for a novel structure with the theme of flexible porosity was introduced. Scaffold models were developed using CATIA V5 for four different porosities. The novel structures made of Poly Amide (PA 2200) material were fabricated using a commercially available Selective Laser Sintering machine (SLS). The differences in scaffold theoretical and experimental porosities were investigated and the percentage of error was discussed.

• Periodical: Applied Mechanics and Materials (Volumes 592-594)
• Pages: 836-841
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.592-594.836
• Online since: July 2014
• Authors: Kishore A. Arul*, Begum S. Rashia, G. Arumaikkannu
• Keywords: Additive Manufacturing (AM), Bone Scaffolds, Polyamide, Porosity, Selective Laser Sintering

References

[1] Tan, K.H., Chua, C.K., Leong, K.F. and Cheah, C. M, Scaffold development using selective laser sintering polyetheretherketone-hydroxyapatite biocomposite blends, Biomaterials, Vol. 26 (2005), P. 4281.

DOI: 10.1016/s0142-9612(03)00131-5

[2] Mikos A.G., Georgious Sarakinos, Michelle.D. Lyman, Donald E. Ingber, Jeseph.P. Vacanti and Robert Langer, Prevascularization of porous biodegradable polymers, Biotechnology and Bioeng Vol. 42, No. 6 (1993), P. 716.

DOI: 10.1002/bit.260420606

[3] Bruder, S. P, The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defect, J Bone Joint Surg Am , Vol. 80 No. 7 (1998), P. 985.

DOI: 10.2106/00004623-199807000-00007

[4] Linbo,W. and Jiandong, D, Compression Molding of Porous Scaffolds with complicated shape for Tissue Engineering, Polymer Material Science and Engineering, Vol. 25 No. 1. (2005), P. 296.

[5] Deville, S., Saiz, E., Tomsia, A. P, Freeze casting of hydroxyapatite scaffolds for bone tissue Engineering, Biomaterials, Vol. 27 (2006), P. 5480.

DOI: 10.1016/j.biomaterials.2006.06.028

[6] Madihally, S.V. and Howard, W. T, Porous chitosan Scaffolds for tissue engineering, Biomaterials, Vol. 20 (1999),P. 1133–42.

DOI: 10.1016/s0142-9612(99)00011-3

[7] Junmin, Q., Kai.C., Hao A. and Zhihao, J, Progress in research of preparation technologies of porous ceramics, Ordnance Material Science and Engineering , Vol. 28 No. 5 (2005), p.60.

[8] S.M. Giannitelli , D. Accoto , M. Trombetta , A. Rainer, Current trends in the design of scaffolds for computer-aided tissue engineering, Acta Biomaterialia Vol. 10 (2014), P. 580.

DOI: 10.1016/j.actbio.2013.10.024

[9] Stefan Lohfeld , Senan Cahill , Valerie Barron , Peter McHugh , Lutz Dürselen , Ludwika Kreja , Christine Bausewein , Anita Ignatius, Fabrication, mechanical and in vivo performance of polycaprolactone/tricalcium phosphate composite scaffolds, Acta Biomaterialia Vol. 8 (2012).

DOI: 10.1016/j.actbio.2012.05.018

[10] Shaun Eshraghi, Suman Das, Mechanical and microstructural properties of polycaprolactone scaffolds with one-dimensional, two-dimensional, and three-dimensional orthogonally oriented porous architectures produced by selective laser sintering, Acta Biomaterialia Vol. 6 (2010).

DOI: 10.1016/j.actbio.2010.02.002

[11] Qin Lian, Di-Chen Li, Yi-Ping Tang, Yong-Rui Zhang, Computer modeling approach for a novel internal architecture of artificial bone, Computer Aided Design (2006).

DOI: 10.1016/j.cad.2005.12.001

[12] M. Sugavaneswaran , G. Arumaikkannu, Modelling for randomly oriented multi material additive manufacturing component and its fabrication, Materials and Design Vol. 54 (2014), P. 779.

DOI: 10.1016/j.matdes.2013.08.102

[13] R.D. Goodridge, C.J. Tuck, R.J.M. Hague, Laser sintering of polyamides and other polymers, Progress in Materials Science Vol. 57 (2012), P. 229.

DOI: 10.1016/j.pmatsci.2011.04.001

[14] B. Caulfield, P.E. McHugh, S. Lohfeld, Dependence of mechanical properties of polyamide components on build parameters in the SLS process, Journal of Materials Processing Technology Vol. 182 (2007), P. 477–488.

DOI: 10.1016/j.jmatprotec.2006.09.007

[15] Tancred, D.C., McCormack, B.A. O, A synthetic bone implant macroscopically identical to cancellous bone, Biomaterials, Vol. 19 (1998), P. 2303.

DOI: 10.1016/s0142-9612(98)00141-0

[16] Atwood, R.C., Jones, J.R., Lee, P. D, Analysis of pore interconnectivity in bioactive glass foams using X-ray microtomography, Scripta Materialia, Vol. 51(2004), P. 1029.

DOI: 10.1016/j.scriptamat.2004.08.014