Effect of Polysaccharide from Tricholoma Matsutake on TNF-α and IL-2

Tan Li; Ming Zhu; Ming Yue Zhai; Ye Shen; Gang Lv; Xin Sun

doi:10.4028/www.scientific.net/AMM.644-650.5435

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vols. 644-650Effect of Polysaccharide from Tricholoma Matsutake...

Effect of Polysaccharide from Tricholoma Matsutake on TNF-α and IL-2

Abstract:

The effects of the polysaccharide extracted from Tricholoma matsutake on the immune response of Sarcoma180 bearing mice were evaluated. Mice were treated with two doses of polysaccharideL-2(1,10mg/kgbodyweight) for 10 days. The concentration of tumor necrosis factor-alpha (TNF-α), interferon-2(IL-2) in mice serum and TNF-α mRNA expression were determined. The concentration of TNF-α in serum increased significantly in two doses groups compared to the model control group, but IL-2 not. The level of TNF-α mRNA transcription increased significantly in two doses groups to the model control group. Results of these studies demonstrated the polysaccharide significantly promoted TNF-α production, immunity potentiating and anti-tumor effects of the polysaccharide were associated with its potentiation of TNF-α mRNA expression at the transcriptional level.

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Periodical:

Applied Mechanics and Materials (Volumes 644-650)

Pages:

5435-5438

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.644-650.5435

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Online since:

September 2014

Authors:

Tan Li, Ming Zhu, Ming Yue Zhai, Ye Shen, Gang Lv, Xin Sun*

Keywords:

Interferon-2, Polysaccharide, Tricholoma Matsutake

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