Electrospun Nanofibers for Fast Dissolution of Naproxen Prepared Using a Coaxial Process with Ethanol as a Shell Fluid

Yong Hui Wu; Deng Guang Yu; Hua Chuan Li; Dao Ning Feng

doi:10.4028/www.scientific.net/AMM.662.29

Paper Titles

The Limy Composite Binder with the Use of the Synthesized Aluminosilicates
p.11

A New Geometric Model for Three-Dimensional Braided Composites
p.15

Dielectric Relaxation Measurements in La_1.94Ba_0.06Mo₂_-_yW_yO₉_-_δ (y=0, 1.0) Oxide-Ion Conductors
p.20

Mechanical Properties of Polypropylene Fiber Concrete after High Temperature
p.24

Electrospun Nanofibers for Fast Dissolution of Naproxen Prepared Using a Coaxial Process with Ethanol as a Shell Fluid
p.29

Study on Mg-Y-Mishmetal-Zr Alloy Melt Reaction
p.33

The Influence of Modified Polytetrafluoroethylene(PTFE) on the Properties of PA6/PTFE Blends
p.38

Experimental Study on De-Fluorinating by Adding Dilute Alkali in Wet Phosphoric Acid Extraction Organic Phase
p.46

Problems and Countermeasures in the Application of the Fire Chemical Detection Equipment Based on Material Properties
p.51

HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 662Electrospun Nanofibers for Fast Dissolution of...

Electrospun Nanofibers for Fast Dissolution of Naproxen Prepared Using a Coaxial Process with Ethanol as a Shell Fluid

Abstract:

The present paper reports a new type of medicated nanofibers loaded with naproxen, which were fabricated using a coaxial electrospinning process with only ethanol as the shell fluid. Field emission scanning electron microscopic observations clearly showed that high quality linear nanofibers with smooth surface and an average diameter of 270 ± 60 nm were generated under a shell-to-core fluid rate ratio of 0.2. X-ray diffraction patterns suggested that the drug was distributed homogeneously in the polymer matrix. In vitro dissolution tests demonstrated that the nanofibers could release the entire contained drug in one minute, whereas the commercial naproxen dispersible tablets took over 40 minutes to exhaust all the drug. The coaxial electrospinning process can provide new way for developing novel drug delivery systems.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Applied Mechanics and Materials (Volume 662)

Pages:

29-32

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.662.29

Citation:

Cite this paper

Online since:

October 2014

Authors:

Yong Hui Wu*, Deng Guang Yu, Hua Chuan Li, Dao Ning Feng

Keywords:

Coaxial Electrospinning, Drug Delivery Systems, Fast Dissolution, Medicated Nanofibers

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

* - Corresponding Author

References

[1] D. G. Yu, J. M. Yang, C. Branford-White, P. Lu, L. Zhang, and L. M. Zhu. Int. J. Pharm. Vol. 158 (2010), p.400.

Google Scholar

[2] D. G. Yu, W. Qian, X. Wang, Y. Li, W. J. Lu, and Y. Zhang, Adv. Mater. Res. Vol. 326 (2013), p.675.

Google Scholar

[3] D. G. Yu, X. X. Shen, C. Branford-White, K. White, L. M. Zhu, and S. W. A. Bligh, Nanotechnology Vol. 20 (2009), p.055104.

DOI: 10.1088/0957-4484/20/5/055104

Google Scholar

[4] T. Vasconcelos, B. Sarmento, and P. Costa P, Drug Discov. Today Vol. 12 (2007), p.1068.

Google Scholar

[5] K. Dhirendra, S. Lewis, N. Udupa, and K. Atin, Pak. J. Pharm. Sci. Vol. 22 (2009), p.234.

Google Scholar

[6] D. G. Yu, C. Branford-White, K. White, X. L. Li, and L. M. Zhu, AAPS PharmSciTech Vol. 11 (2010), p.809.

DOI: 10.1208/s12249-010-9438-4

Google Scholar

[7] C. Li, D. G. Yu, G. R Williams, and Z. H. Wang, PLOS One Vol. 9 (2014), p.92106.

Google Scholar

[8] K. C. Duggan, M. J. Walters, J. Musee, J. M. Harp, J. R. Kiefer, J. A. Oates, and L. J. Marnett, J. Biol. Chem. Vol. 285 (2010), p.34950.

DOI: 10.2210/pdb3nt1/pdb

Google Scholar