Storage tanks after earthquake disaster may create the serious consequence, so their anti-seismic problems have drawn greater attention, and their seismic response become the focus of research. Considering the liquid-solid coupling and the interaction between foundation and storage tanks，three different volumes of storage tanks that have different liquid height were simulated under the earthquake using the software ADINA. The liquid sloshing wave height, peak acceleration of tank wall and hydrodynamic pressure were analyzed. The results show that the peak sloshing wave height shows a rising trend basically with the increase of liquid height, and the roofs of large tanks are more easier to be destroyed by liquid sloshing. With the increase of liquid height and tank volume, the response of peak acceleration is greater. The hydrodynamic pressure increases with the decrease of liquid height. Near the bottom of tank wall the value of hydrodynamic pressure is relatively large, so elephant foot buckling is easier to happen in that area.