Hydrogel Scaffold Fabricated by 3D Printing & Ultrasonic Spraying

Article Preview

Abstract:

This paper presents a novel strategy for fabricating hydrogel scaffold at ambient temperature by 3D printing supplemented with an ultrasonic spraying which involves crosslink reaction. The contradictory between the rheological properties and solidification of natural biological material for machinability and formability respectively at ambient temperature was solved. The gelled fraction and porosity were measured respectively to study the influence of crosslinking agent. The results showed that the two subjects appear a parabolic trend with the concentration of CaCl2 from 2% to 4%, but the tolerance of aperture decreases monotone.

You might also be interested in these eBooks

Info:

Periodical:

Pages:

336-339

Citation:

Online since:

October 2014

Authors:

Export:

Price:

Permissions CCC:

Permissions PLS:

Сopyright:

© 2014 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

* - Corresponding Author

[1] D.A. Rees, Polysaccharide shapes and their interactions—some recent advances, Pure Appl. Chem., 53 (1981) 1-14.

Google Scholar

[2] W.R. Gombotz, F.W. Siow, Protein release from alginate matrices, Advanced Drug Delivery Reviews, 64 (2012) 194-205.

DOI: 10.1016/j.addr.2012.09.007

Google Scholar

[3] X.Y. Zhu, D.C. Li, Biomanufacturing and Bionic Manufacturing Science, in: J. Zhong, et al. (Eds. ), Mechanical engineering discipline development strategy report (2011~2020), Science Press, Beijing, 2010, pp.168-172.

Google Scholar

[4] D.Y. Park, C.H. Mun, E. Kang, D.Y. No, J. Ju, S.H. Lee, One-stop microfiber spinning and fabrication of a fibrous cell-encapsulated scaffold on a single microfluidic platform, Biofabrication, 6 (2014) 024108.

DOI: 10.1088/1758-5082/6/2/024108

Google Scholar

[5] D.L. Liu, Y.Y. Liu, Q.G. WANG, Q.X. Hu, Multiphysics coupling analysis and experiment of low-temperature deposition manufacturing and electrospinning for multi-scale tissue engineering scaffold, Chinese Journal of Mechanical Engineering, 48 (2012).

DOI: 10.3901/jme.2012.15.137

Google Scholar

[6] X.M. Lin, J. Zhao, W.Y. Si, Z.H. Song, Procyanidins crosslinking of the scaffold materials biocompatibility research, New progress in ophthalmology, 27 (2007) 262-265.

Google Scholar

[7] J.D. Sherwood, F. Risso, Rates of transport through a capsule membrane to attain Donnan equilibrium, Journal of Colloid and Interface Science, 263 (2003) 202-212.

DOI: 10.1016/s0021-9797(03)00140-1

Google Scholar

[8] E. Favrea, M. Leonard, A. Laurent, E. Dellacherie. Diffusion of polyethyleneglycols in calcium alginate hydrogels, Colloids and Surfaces, 194 (2001) 197-206.

DOI: 10.1016/s0927-7757(01)00789-0

Google Scholar