The porous NiO/ samaria doped ceria (SDC) cermets, which have been used as the anode-supported for solid oxide fuel cell (SOFC), are fabricated via the tape casting process. In this article using different kinds of slurry system, prepared the large size (60×60mm) anode substrates for SOFC successfully. Effects of solvent, dispersant, plasticizer, binder and the sintering temperature program were investigated. Experimental results show that thicknesses and pore rates of anode substrates are 0.6 ~ 1.5mm and 20% ~ 40% respectively. And all of the complete and flat anode substrates have highly support intensity, for their homogeneous microstructure and pore distribution. Sintering the green pieces of anode substrates at the temperature of 1300°C for 2h, different green pieces have different shrinkages that could be from 20% to 30% measuring with thermal dilatometer. Using this kind of anode substrate, could find out a perfect one to matching the electrolyte film easily.