Chemometric and Experimental Investigations of Organogelation Based on β-Cyclodextrin

Amornrat Klaewklod; Vimon Tantishaiyakul; Tanatchaporn Sangfai; Namon Hirun; Supagorn Rugmai

doi:10.4028/www.scientific.net/AMR.1060.133

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 1060Chemometric and Experimental Investigations of...

Chemometric and Experimental Investigations of Organogelation Based on β-Cyclodextrin

Abstract:

The evaluation of PEG as a gelation solvent for an organogel based on β-cyclodextrin (β-CyD) was investigated using principal component analysis (PCA). The test tube tilting method was performed to examine the gel formation experimentally. The important descriptors used in the PCA included the Hansen partial solubility parameters. LogP may be able to be used as an additional descriptor for this system. According to PCA analysis, PEG was in a cluster of gelation solvents. Subsequently, various PEG liquid state grades were tested for their ability to gel the system and PEG400 was found to be able to produce a gel. This verifies that PCA can be successfully used to evaluate the role of PEG. Accordingly, this PCA method may be an effective tool to evaluate the role of any solvent for other low molecular weight gelators (LMWGs). Afterwards, the optimal components in the system were explored, and it was found to be 0.1M β-CyD, 0.5M K₂CO₃ in PEG400. Based on WAXS, the gel fiber of this organogel was demonstrated to be amorphous. This forming organogel will be further characterized in details and investigated for use in a drug delivery system.

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Advanced Materials Research (Volume 1060)

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133-136

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1060.133

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Online since:

December 2014

Authors:

Amornrat Klaewklod, Vimon Tantishaiyakul*, Tanatchaporn Sangfai, Namon Hirun, Supagorn Rugmai

Keywords:

LMWG, Organogel, PCA, WAXS, β-Cyclodextrin

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