N-Benzyl Chitosan In Situ Forming Antimicrobial Gel for Periodontitis Treatment

Abstract:

The objectives of research were to synthesize N-benzyl chitosan and to investigate N-benzyl chitosan on the properties of in situ forming gel such as viscosity, syringeability, drug release and antimicrobial activity against Porphyromonas gingivalis. N-benzyl chitosan was synthesized and determined by FTIR. The increased amount of N-benzyl chitosan apparently increased the viscosity and syringeability of this system. N-benzyl chitosan gel could prolong the release of doxycycline hyclate and showed the antimicrobial activity against Porphyromonas gingivalis. N-benzyl chitosan systems could be delivered from syringe through needle for periodontitis treatment.

• Periodical: Advanced Materials Research (Volume 1060)
• Pages: 159-163
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1060.159
• Online since: December 2014
• Authors: Jongjan Mahadlek*, Warayuth Sajomsang, Thawatchai Phaechamud
• Keywords: In Situ Forming Gel, N-Benzyl Chitosan, Periodontitis Treatment

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