Formulation and Physicochemical Evaluation of Topical Preparations Containing Extract of Clerodendrum disparifolium

Abstract:

Clerodendrum disparifolium is a Thai herbal medicine, which is used for the treatment of insect bites and sting reactions by applying finely crushed leaves to the inflamed area. However, this usage is inconvenient. The study aimed to develop gel-and cream-based formulations containing 0.5 %w/v of C. disparifolium extract, and evaluate their physicochemical properties. Different topical formulations were prepared using Carbopol 934 for gels and stearic acid for creams by varying their concentrations. The results showed that gel-based formulation containing Carbopol 934 in the range of 0.5-1.0 %w/w had good appearance, appropriate spreadability (7.30-8.70 cm) and viscosity (33,100-68,920 centipoise (cps)). The pH of gel-based formulation ranged from 6.01 to 6.11. For cream-based formulation containing 10-12 % w/w of stearic acid exhibited good physicochemical characteristics. The spreadability, viscosity and pH were 5.00-5.50 cm, 110,050-174,900 cps and 6.03-6.08, respectively. The results provided the suitable formulations, which should be continuously developed for large-scale pharmaceutical production.

• Periodical: Advanced Materials Research (Volume 1060)
• Pages: 95-98
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1060.95
• Online since: December 2014
• Authors: Nawinda Chinatangkul*, Narumol Phosrithong, Nantana Nuchtavorn, Teedanai Rattanapit, Chonnawat Mongkol, Poompat Chutipanyaboot
• Keywords: Carbopol, Clerodendrum disparifolium, Stearic Acid, Topical Formulation

References

[1] N. Phosrithong, C. Rattanachot, A. Insook, N. Rimpoongoen, J. Jiaranaikulwanitch and N. Nuchtavorn: Proceeding of the 7th Pure and Applied Chemistry International Conference (PACCON2013), 2013 January 23-25; Chonburi, Thailand, pp.290-293.

[2] N. Shrivastava and T. Patel: Medicinal Aromatic Plant Sci. Biotech. Vol. 1(1) (2007), pp.142-150.

[3] A.A.M. Lira, E.A. Sester, L.R. Abreu, L.B.L. Silva and D.P. Santana: Braz. J. Pharm. Sci. Vol. 40 (2004), p.35–41.

[4] Y.E. Hamza, A.M. Molokhia, I.I. Soliman, F.H. Ahmed and N.A. Soliman: Az. J. Pharm. Sci. Vol. 29 (2002), p.412–432.

[5] L.V. Allen, N.G. Popovich and H.C. Ansel: Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems 9th ed. (Lippincott Williams & Wilkins, Philadelphia 2011).

[6] P. Kumar, S. Mishra and A. Malik: Int. J. Med. Health Pharm. Biomed. Eng. Vol. 7(1) (2013), pp.12-14.

[7] B. Vennat, D. Gross and A. Pourrat: STP Pharm. Sci. Vol. 4(6) (1994), pp.453-457.

[8] L. Buhse, Y. Chiu, C. Chen, J. Wilkin and H. Carlin: Proceeding of center for drug evaluation and research meeting, 2003 Mar 12-13; Maryland, USA, pp.61-103.