Determination of Henry Constants of Azelnidipine Enantiomers on Chiralpak AD Column at Different Temperatures

Abstract:

Simulated moving bed (SMB) chromatographic separation has become a highly promising method for chiral separation due to the less solvent consumption and efficient utilization of stationary phase. As reported, Azelnidipine exists two isomeric forms, it is necessary to product azelnidipine single enantiomer for medical safety and drug developmen. However, the separation of azelnidipine enantiomers on SMB is complex, requiring many operating parameters. And the SMB processes with temperature gradient (non-isotherm) mode may have significant advantages over the traditional isothermal mode. In this article, the Henry constants of azelnidipine enantiomers were determined with pulse experiments on Chiralpak AD column at different temperatures. It provided important references for the production of azelnidipine single enantiomer with non-isotherm SMB.

• Periodical: Advanced Materials Research (Volume 1078)
• Pages: 78-81
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1078.78
• Online since: December 2014
• Authors: Ying Ying Fang, Xiao Ling Zha, Hui Li, Wei Fang Yu*
• Keywords: Azelnidipine Enantiomers, Chromatographic Separation, Henry Constants

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DOI: 10.1021/ie000825h