Synthesis of 5-(4-nitrophenyl)-2-aminopyrazine

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Abstract:

5-(4-nitrophenyl)-2-aminopyrazine (13) was synthesized from 2-aminopyrazine (9) through two steps including monobrominated reaction, Suzuki-Miyaura coupling and the structures were confirmed by 1H NMR and MS spectrum. The synthetic method of 13 was optimized and can be used to synthesize 5-(4-nitrophenyl)-2-aminopyrazine derivatives.

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67-70

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December 2014

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© 2015 Trans Tech Publications Ltd. All Rights Reserved

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[1] T. Hirano, T. Nakagawa, A. Kodaka, et al. Res. Chem. Intermed., Forum Vol. 39(2013), pp.233-245.

Google Scholar

[2] T. Hirano, Y. Takahashi, H. Kondo, et al. Photochem. Photobiol. Sci., Forum Vol. 7(2008), pp.97-207.

Google Scholar

[3] F. D. Wael, P. Jeanjot, C. Moens, et al. Bioorg. Med. Chem. Lett., Forum Vol. 17(2009), pp.4336-4344.

Google Scholar

[4] Takahashi, Toshiyuki, et al. Bioorg. Med. Chem. Lett., Forum Vol. 19(2009), pp.3511-3516.

Google Scholar

[5] T. Itoh, S. Kato, N. Nonoyama, et al. Org. Process Res. Dev., Forum Vol. 10(2006), pp.822-828.

Google Scholar

[6] T. Itoh, K. Maeda, T. Wada, et al. Tetrahedron Lett., Forum Vol. 43(2002), pp.9287-9290.

Google Scholar

[7] K. Mrinalkanti, K. Neelima, et al. Patent WO2007096764A(1). (2007).

Google Scholar

[8] G. Germano, C. Andrea, V. Salvatore, et al. Patent WO2011007314A(1). (2011).

Google Scholar

[9] R. Saito, A. Ohno and E. Ito. Tetrahedron, Forum Vol. 66(2010), pp.583-590.

Google Scholar

[10] J. Albaneze-Walker, M. Zhao, M. D. Baker, et al. Tetrahedron Lett., Forum Vol. 43(2002), pp.6747-6750.

Google Scholar