Experimental Investigation of 99mТс-Nanotech Used for Lymph Nodes Visualization

Ivan Sinilkin; Vladimir Chernov; Anna Titskaya; Roman Zelchan; Natalya Daneikina

doi:10.4028/www.scientific.net/AMR.1084.389

Paper Titles

Diagnostic Efficiency of Single-Photon Emission Computed Tomography with ^99MTc-MIBI in Visualization of Malignant Tumors of the Larynx and Laryngopharynx
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Dynamic Renoscintigraphy with 99mTc-DTPA in the Evaluation of Renal Function in Patients with Chronic Heart Failure
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Electroporation Application as an Alternative to Radiation Therapy
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Evaluation of Functional Factors and Life Quality of Patients with Parotid Gland Cancer after Multimodal Treatment Including Radiation Therapy
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Experimental Investigation of ^99mТс-Nanotech Used for Lymph Nodes Visualization
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Immediate and late Clinical Outcomes in Patients with Head and Neck Cancer Treated at the Ural Neutron Center
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Methods of Synthesis of Radiopharmaceuticals Based on Fatty Acids Marked with ⁹⁹^mTc and Perspectives of their Application
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Multimodality Treatment of Locally-Advanced Breast Cancer Using 6.3 MeV Fast Neutrons and Quality of Life in Patients in Long-Term Follow-Up
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Neutron and Neutron-Photon Therapy for Head and Neck Cancer
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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 1084Experimental Investigation of 99mТс-Nanotech Used...

Experimental Investigation of ^99mТс-Nanotech Used for Lymph Nodes Visualization

Abstract:

Measurement of colloidal particles size was performed on a NICOMP 380 ZLS. Pharmacokinetics. Radiometry of the organs was carried out on γ-spectrometer. Measurement of the sizes of radioactive particles of ^99mTc-nanotech showed that average dynamic diameter of RFP particle ranged from 16.7 to 24.5 nm. ^99mTc-nanotech received by the blood is actively trapped by liver and spleen. Inguinal lymph node in all animals was clearly visualized during lymphoscintigraphy on the 15^th minute. Maximum accumulation of ^99mTc-nanotech was observed in 3 hours. Experimental study of radiopharmaceutical ^99mTc-nanotech showed that the nanocolloid can be used for lymphoscintigraphy and visualization of “sentinel” nodes.

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Periodical:

Advanced Materials Research (Volume 1084)

Pages:

389-392

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1084.389

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Online since:

January 2015

Authors:

Ivan Sinilkin, Vladimir Chernov, Anna Titskaya, Roman Zelchan*, Natalya Daneikina

Keywords:

^99mTc-Nanocolloid, Lymphoscintigraphy, Sentinel Lymph Node

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