Concrete deformation due to temperature and moisture condition will always develop simultaneously and interactively. The numerical simulation of hygro-thermal deformation of concrete is necessary to be investigated for better serviceability, durability estimation and life prediction. In this paper, a numerical simulation procedure was proposed for hygro-thermal deformation of concrete based on the principle of heat and moisture transfer in porous medium. The procedure comprised an analytic solution of heat and moisture transfer, a calculation of moisture induced stress and a finite element analysis (FEM) of hygro-thermal deformation. The methodology of a software named Coupling Temperature and Moisture Simulation System for concrete (CTMSoft) was represented and developed by a mix programming. The graphical user interface (GUI) of the software was programmed by Visual Basic 6.0 and its real numerical calculation process was conducted by calling Matlab and ANSYS. The efficiency of the CTMSoft was validated by a case analysis of the data of Hundt’s test.