Inclusion Process of Curcuminoid-β-Cyclodextrin Complex and its Stability
Curcuminoid is an important natural product, but it is water insoluble, and sensitive to light, pH, solvent system, and oxygen.The inclusion process of curcuminoid-β-CD complex was investigated by the orthogonal experiment, and the stability of curcuminoid-β-CD complex was studied under different conditions. The results show that the encapsulation rate is 87.34% under optimized conditions of temperature 50 , time 1.5 h and material ratio 1:30(wcurcuminoid : wβ-CD). The stability of curcuminoid-β-cyclodextrin complex increases compared to curcuminoid. Therefore, the complex formation of curcuminoid with β-CD is an effective method to improve the stability of curcuminoid.
Zhengyi Jiang, Jingtao Han and Xianghua Liu
X. Z. Li et al., "Inclusion Process of Curcuminoid-β-Cyclodextrin Complex and its Stability", Advanced Materials Research, Vols. 152-153, pp. 1487-1491, 2011