Preparation of Folate Conjugated O-Carboxymethyl Chitosan Nanoparticles

Abstract:

Anticancer drugs are always restricted as lacking of tumor cell-selective targeting. In this paper, to achieve double effects of targeting and decreasing the drug toxicity, the folate (FA) -O-carboxymethyl chitosan (O-CMC) and the methotrexate (MTX) encapsulated FA-O-CMC/CaCl2 nanoparticles were prepared. The numbers of FA conjugated to O-CMC, particle size, surface morphology, encapsulation efficiency and loading efficiency of the obtained nanoparticles were characterized. The results showed that the FA-O-CMC possessing targeting ability was achieved. MTX had been successfully loaded into the nanoparticles. The prepared nanoparticles were spherical in morphology with an average size of 322 nm

• Periodical: Advanced Materials Research (Volumes 152-153)
• Pages: 1797-1800
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.152-153.1797
• Online since: October 2010
• Authors: Jin Gou Ji, Dan Jun Wu, Jing Fen Zhang, Jing Jie Li, Yi Xu
• Keywords: Carboxymethyl Chitosan, Folate (FA), Methotrexate, Nanoparticle, Targeting

References

[1] D. Banerjee, K. P Mayer, G. Capiaux : Biochim. Biophys Acta. Vol. 1587(2002), p.164.

[2] K. Riebeseel, E. Biedermann, R. Loser: Bioconjugate Chem., Vol. 13(2002), p.773.

[3] M. George, T.E. Abraham: J of Control Release. Vol. 114(2006), p.1.

[4] A. Anitha, V.V. Divya Rani, R. Krishna: Carbohydr. Polym. Vol. 78(2009), p.672.

[5] H.Z. Zhao, L. Yue, Y. Lanry: Int. J. Pharm. Vol. 349(2008), p.256.

[6] M. Hartman, E.A. van, J.L. Severens: J Rheumatol. Vol. 31(2004), p.902.

[7] B. Stella, S. Arpicco, M.T. Peracchia: J Pharm Sci. Vol. 89(2000), p.1452.

[8] Y. J Lu, P. S Low: Adv Drug Deliver Rev. Vol. 54(2002), p.675.