Preparation of Folate Conjugated O-Carboxymethyl Chitosan Nanoparticles

Abstract:

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Anticancer drugs are always restricted as lacking of tumor cell-selective targeting. In this paper, to achieve double effects of targeting and decreasing the drug toxicity, the folate (FA) -O-carboxymethyl chitosan (O-CMC) and the methotrexate (MTX) encapsulated FA-O-CMC/CaCl2 nanoparticles were prepared. The numbers of FA conjugated to O-CMC, particle size, surface morphology, encapsulation efficiency and loading efficiency of the obtained nanoparticles were characterized. The results showed that the FA-O-CMC possessing targeting ability was achieved. MTX had been successfully loaded into the nanoparticles. The prepared nanoparticles were spherical in morphology with an average size of 322 nm

Info:

Periodical:

Advanced Materials Research (Volumes 152-153)

Edited by:

Zhengyi Jiang, Jingtao Han and Xianghua Liu

Pages:

1797-1800

DOI:

10.4028/www.scientific.net/AMR.152-153.1797

Citation:

J. G. Ji et al., "Preparation of Folate Conjugated O-Carboxymethyl Chitosan Nanoparticles", Advanced Materials Research, Vols. 152-153, pp. 1797-1800, 2011

Online since:

October 2010

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Price:

$35.00

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