The serpentine is a kind of phyllosilicates whose crystal structure leads to a tetrahedral-octahedral (TO) structure. Because of its unique crystal structure, micro-nano serpentine powders (MSP) in liquid lubricants can show a good tribological performance, so that lots of scholars had started extensive and in-depth studied on its tribological performance. In this research, the raw material which is Xiuyan serpentine produced from Liaoning province, China, had been made into powders with particle average diameter about 0.5 μm. The friction optimized content of MSP in the lubricant oil was studied and it were examined that the loads’ and friction pairs move velocity’s changes had effect to tribological performance in friction course. The results show that the optimal content of MSP in gasoline engine oil SJ10W-40 is 0.5 mass%, under this condition, friction coefficient can be reduced to 0.03, and the friction-reduction performance can been enhanced by 73.3%, so that the lubrication state is that boundary lubrication changes into mixed lubrication. Disclosing the tribological rule of MSP in lubricant oil under the condition of loads and the move velocity of friction pairs changing, and discovering MSP addictive to lubricant oil can extended friction pairs with high move speed and heavy loads working hours, all that can provide a theoretical basis to promote engineering.