Synthesis and Characterization of Sugar-Bearing Chitosan Derivatives as a Scaffold for Nitric Oxide Release
These new synthesized diazeniumdiolates obtained from D-gluconic acid-bearing chitosan derivatives (SBC) with different molecular weight (280 kDa and 880 KDa) and D-gluconic acid-bearing O-carboxymethyl chitosan derivatives (880 KDa) (SBCS) were used as the NO donor species. Compared with SBC with much higher molecular weight (880 KDa), the SBC with the lower molecular weight (280 kDa) exhibited a high storage capacity for NO (up to 408 nmol NO/mg), greatly increasing the “payload” of released NO with the molecular weight of SBC decreasing. The NO release durations (0.326 h) observed for secondary amine on the SBC with the lower molecular weight (280 kDa) were slightly higher than that of SBC diazeniumliolates with the higher molecular weight (880 kDa), which was only 0.294h. The release duration of SBCS-NO adducts (0.381h) was obviously longer than that of SBC-NO adducts, when they have the same molecular weight (880 kDa).
Guojun Zhang and Jessica Xu
Y. Sun and Y. Liu, "Synthesis and Characterization of Sugar-Bearing Chitosan Derivatives as a Scaffold for Nitric Oxide Release", Advanced Materials Research, Vols. 160-162, pp. 1083-1089, 2011