Taking Harbin west railway station as the researching object, the wind load distribution as well as its effects, which are widely used in practice, is investigated. First, wind pressure distribution on a rigid model is measured simultaneously in a wind tunnel. Some special characteristics of the measured wind pressure, especially its fluctuating component, are discussed. Then the fluctuating wind pressure field is reconstructed based on the synchronous multi-pressure scanning technique of wind tunnel tests and the proper orthogonal decomposition (POD) technique. The influence of lower RC structure on wind-induced vibration is investigated using non-linear time-history analysis. At last, a new method is introduced to obtain equivalent static wind load (ESWL) that reproduce all largest load effects at the same time. With the synthetic application of above methods, the problems such as: complex time and spatial distribution of fluctuating wind; multi-mode vibration of wind-induced response; multiple equivalent objectives for ESWL, can be solved efficiently.