Adopting the two systems-common base and base isolation and inputting El-Centro wave as the earthquake wave, in this paper, comparative analysis of structure’s earthquake-resistant performance was conducted on a 6-layer custom steel structure residence in Changzhou area. The result shows that the gradually matured isolated technology can be applied to steel structure as well, which means the isolated steel structures possess the same characteristics as other isolated structures. With the satisfaction of required bearing capacity, the structural reaction to earthquake has been effectively reduced and its safety has been guaranteed after considering the isolation of steel structure residence; moreover, the storey accelerations reaction has also been greatly declined, meeting higher requirements towards comfortableness of residence structure. Meanwhile, by nonlinear dynamic analysis of simple Bouc-Wen hysteretic model, the requirement towards the biggest ductility was discussed and a brief analysis of the life cycle cost of this residence was worked out. The analysis result demonstrates that the isolation layer has effectively controlled the vibration of superstructure, which would contribute to the reduction of seismic hazard.