In order to analyze the influences of axial compression ratio and loading speed to the dynamic response and failure mode of RC columns subjected to blast loading, the collapse test for 6 reinforced concrete column models were conducted. Results show that there are three kinds of failure types: shear failure, flexural failure, flexural-shear failure. It tends to failure in shear mode when compression ratio is 0, and tends to failure in flexural or in flexural-shear mode when compression ratio is 0.5 and 0.25 respectively. The peak value of the exerted load and end moment will increase with the increasing of axial compression ratio in the first stage (approximately when compression ratio is less than 0.25) and then will decrease. The peak value of extra axial forces will decrease with the increasing of axial compression ratio.