According to the method of semi-immersion in 5% sodium sulfate solution, the property against sulfate attack of cement-based materials with various compositions are studied with the indexes of the amount of crystal salt in unit exposing area and the ratio of total mass change. The experiment indicates that the order of mortar with w/c=0.4 against sulfate attack from high to low are SAC 42.5>PO 42.5>Clinker>HAC 42.5. When w/b is constant and the cement was replaced by the same quantity of salic material, the order of mortar against sulfate attack are Clinker> PO 42.5> SAC 42.5> HAC 42.5. The replacement of SAC and HAC with the same quantity of salic material leads to the sharp decrease of its property against sulfate attack while the result is opposite for the clinker serial and PO 42.5 serial. Addition of redispersible polymer powder can lead to decrease of penetration and increase the properties of products to sulfate attack. Then, it comes to the conclusion that multi-binder with PO.42.5cement 70%–80% (quality percentage), and internal mixing of 5%–10% silica fume, 10%–15% fly ash can meet the high corrosion resistance requirements.