In order to solve the problem of untrustworthy interactive process in distributed cooperative manufacturing environment, we proposed a method combining intelligent agent and interactive Process Control. The method inserts a trustworthy interaction management layer between users and information system. The management layer includes 5 agents. Interaction agent and negotiation agent track and collect data of interactive behavior; monitor agent maintain global clock to guaranty temporal consistency; assessment and analysis agent used for determining whether abnormal interactive behaviors; and feedback agent used for giving user prompt and early warning. To use this method, we constructed a trustworthy interaction chain of human-information system based on intelligent agent technology. Due to the each link of the chain is monitoring and managing by the management layer, the trustworthiness of interaction process is guaranteed.